Understanding neurodegeneration through single cell- and organoid-based approaches

Understanding neurodegeneration through single cell- and organoid-based approaches
Theme: Parkinson's disease and other neurodegenerative disorders

Tuesday 25th April, 09:30 – 11:10

Recently developed single-cell and organoid-based experimental approaches are opening new research avenues to better understand neurodegenerative disorders as well as identify novel therapeutic targets. This symposium will bring together representatives from Catalysing a United Response in Europe to Neurodegenerative Diseases (CURE-ND), an alliance formed in 2020 by the Paris Brain institute, DZNE, Mission Lucidity and the UK Dementia Research Institute to promote international scientific collaborations, training initiatives and advocate support for neurodegeneration research. Speakers will present their latest work exploiting the application of cutting-edge single-cell technologies and organoid modelling to identify molecular signatures and important cellular cross-talks underlying neurodegenerative disorders such as Alzheimer's and Parkinson's disease.

  • Giles Hardingham, UK Dementia Research Institute at The University of Edinburgh, UK: Glia-neuronal interactions in Alzheimer's disease (co-chair)
  • Wei-Ting Chen, VIB - KU Leuven Center for Brain and Disease Research, Belgium: Exploiting spatial transcriptomics to understand Alzheimer's disease (co-chair)
  • Benjamin Galet, Paris Brain Institute, France: Lineage-specific molecular profiling in organoid models of Alzheimer's Disease
  • Michela Deleidi, German Centre for Neurodegenerative Diseases (DZNE), Germany: Glucocerebrosidase and Brain Disease: Novel Functions Beyond the Lysosome

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