Frank Bradke

F Bradke

Mechanisms of Axon Growth and Regeneration (plenary 7)
Frank Bradke, DZNE, Germany

17:10 - 18:10 BST, Tuesday 25th April 2023

Frank Bradke is a neurobiologist who works on the physiological regeneration of nerve cells in the central nervous system. In 2016, he was awarded the Gottfried Wilhelm Leibniz Prize for his "pioneering research in the field of regenerative neurobiology." He is currently a Group Leader at the German Center for Neurodegenerative Diseases. He is a member of the Editorial Board for Current Biology.

Research in the Bradke lab at DZNE focuses on how nerve cells grow during development and how these processes can be reactivated to induce nerve regeneration in the injured spinal cord.

Mechanisms of Axon Growth and Regeneration
In this lecture, Frank Bradke will discuss his research on how neurons initially polarize to generate and extend their axon.  He will then show how his group employs the underlying developmental mechanisms to elicit axon regeneration in the adult after a spinal cord injury.

Almost everybody who has seen neurons under a microscope for the first time is fascinated by their beauty and their complex shape.  Early on during development, however, neurons look round and simple without signs of their future complexity.  How do neurons develop their sophisticated structure?  How do they initially generate domains that later have distinct functions within neuronal circuits, such as the axon?  And, can a better understanding of the underlying developmental mechanisms help us in pathological conditions, such as a spinal cord injury, to induce axons to regenerate? 

Here, I will talk about the cytoskeleton as a driving force for initial neuronal polarization and axon growth.  I will then explore how cytoskeletal changes help to reactivate the growth program of injured CNS axons to elicit axon regeneration after a spinal cord injury.  Finally, I will discuss whether axon growth and synapse formation could represent mutually excluding processes.  Following this developmental hypothesis helps us to generate a novel perspective on regeneration failure in the adult CNS and to envisage new paths to overcome it.   Thus, this talk will describe how we can employ developmental mechanisms to induce axon regeneration in the adult after a spinal cord injury.