‘Challenges in ageing: a multisystem account of brain and behaviour’

Wednesday 17th April, 14:00 - 16:00, CCD
Cost: FREE 
Theme: Ageing

Registration: You will be given the option to attend this satellite meeting as part of the registration process for the Festival.

The myriad of neural and vascular conditions our ageing population are at risk of present growing threats to both brain and behavioural health. In light of these challenges, it is critical that we develop multisystem perspectives that can account for brain function, anatomy, neurovascular health, and their relationships with physical and cognitive phenotypes in ageing.

This satellite meeting will explore challenges in ageing, by drawing on the unique neuroimaging, vascular and phenotypic data from the Irish Longitudinal Study on Ageing (TILDA). We will address neural and neurovascular characteristics of ageing within a sample of Irish adults aged over 50.

Talks will include report of novel machine learning methods for predicting cognitive performance in older adults, including a brain-predicted age score derived from structural MRI data. We will address white matter tract integrity in ageing, using novel markers from Diffusion Tensor Imaging and machine learning methods to investigate relationships with objective measures of gait behaviour.

Our latter talks will document neurovascular health in ageing by exploring key determinants of cerebral perfusion using Arterial Spin Labelling. We will appraise neurovascular health in relation to depression, global cognition, and falls, highlighting potential modifiable pathways for early intervention. We will facilitate discussion around the multiple physiological pathways that may act upon neural and physical health, in the context of their impact on cognitive and behavioural phenotypes.

Speakers include:
Rose Anne Kenny, Dept. Medical Gerontology, TCD, Ireland.
Robert Whelan, Trinity College Institute of Neuroscience, Ireland.
Richard Carson, Trinity College Institute of Neuroscience, Ireland.

The Irish Longitudinal Study on Ageing:

The Irish Longitudinal Study on Ageing (TILDA) is one of the largest prospective cohort studies of ageing in the world, currently at its fifth wave of data collection. TILDA comprises a nationally representative cohort of community-dwelling adults aged 50+, with a longitudinal sample size in excess of 5,500. TILDA’s output has been published in leading international journals, including Journal of the American Medical Association, Neurobiology of Ageing, Circulation, Journal of the American Geriatrics Society, and Journal of Gerontology, in addition to informing over 100 policy documents produced by the Irish government.